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Education

• Ph.D. Candidate, Bioengineering (Neuroengineering), Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. Expected graduation date: August 2010.


• B.S. in Biomedical Engineering, Department of Electrical Engineering, Tsinghua University, Beijing China, 2004.

Statement of Research Interests

I am curious about understanding the principles and mechanisms of biological intelligence, and applying them to the engineering of artificial intelligent systems.

My current research focuses on tissue-level neural interfacing technology, in which I am studying the efficient, bidirectional communication between a computer and a neural tissue or muscle enabled by our newly developed conformable microelectrode array (MEA) technology. The nervous system is an analogy to the CPU in computer architecture. It is believed where the intelligence resides. MEAs provide a tool for detecting and observing electrical signals originating from the functioning processes of such systems, making it possible, at a certain degree, to derive information about the source activities, and thus to "spy" the underlying principles and mechanisms. Meanwhile, MEAs also provide a means for delivering control signals to interact with the nervous system, together with the recording capability, making it possible to engineering hybrid systems, such as neural prostheses.

In my current research practice, BioMedical Engineering can be interpreted using the following chart:

My research interests can be reperesented in the following aspects:

• Neural interfacing technology, neural/muscular recording and stimulation
• Neural prosthesis
• MEMS/NEMS
• Principles and mechanisms of biological intelligence
• Neuromorphic engineering

Read more about my research HERE.

Work Experience

• Intern, Axion Biosystems, Atlanta GA, Summer 2009
• Treasurer, IEEE EMB Society Atlanta Chapter (Jan. 2009-Present)
• Graduate Research Assistant, Department of Biomedical Engineering, Georgia Institute of Technology (2005-Present)
• Graduate Teaching Assistant, BMED 4600/4601 Senior Design Projects I/II, Georgia Institute of Technology (Fall 2008)
• Cleanroom User, Microelectronics Research Center, Georgia Institute of Technology (2006-Present)
• Engineer and Project Manager, Beijing Huachuangkangda Technology Co., LTD., China (2004-2005)

Memberships

• Student Member, Society for Neuroscience (2006, 2009)
• Student Member, Institute of Electrical and Electronics Engineers (IEEE) (2007, 2009)
• Student Member, Materials Research Society (2007-2008, 2009-2010)
• Member, Institute of Neuromorphic Engineering (2007-Present)
• Board Member, Tsinghua Alumni Association of Georgia (2008-Present)

Patents

1. L. Guo and S. P. DeWeerth, "Multilayer Via-Bonding Technology with Batch Processing Capability for High-Density, High-Resolution Chip Packaging," Invention Disclosure.


2. L. Guo, S. P. DeWeerth, A. M. Klein, and E. A. Brown, "Open- and Closed-Loop Synergistic Muscular Control Using Microelectrode Arrays," Invention Disclosure.


3. L. Guo and S. P. DeWeerth, "Epimysial Recording and Stimulation Using Microelectrode Arrays," Invention Disclosure.


4. L. Guo and S. P. DeWeerth, "Fabrication of Multilayer Wiring Interconnects on PDMS Substrate," Provisional.


5. L. Guo and S. P. DeWeerth, "A Method for Fabricating Conical-Well Microelectrode Arrays," Provisional.

Publications

1. L. Guo and S. P. DeWeerth, "High-Density PDMS-Based Conformable Microelectrode Arrays for Neural Surface Stimulation and Recording: An Integrated System Solution," in preparation.


2. L. Guo and S. P. DeWeerth, "High Integration Elastronics: Toward an Integrated Multilayer Composite," in preparation.


3. K. W. Meacham, L. Guo, S. Hochman, and S. P. DeWeerth, "Selective Activation of the Spinal Cord Using a Surface-Stimulating Microelectrode Array," in preparation.


4. L. Guo, K. W. Meacham, S. Hochman, and S. P. DeWeerth, "A PDMS-Based Conical-Well Microelectrode Array for Surface Stimulation of Neural Tissues," in preparation.


5. S. A. Desai, J. D. Rolston, L. Guo, and S. M. Potter, "Improving Impedance of Implantable Micro-Wire Multi-Electrode Arrays by Ultrasonic Electroplating of Durable Platinum Black," in preparation.


6. K. W. Meacham, R. J. Giuly, L. Guo, S. Hochman, and S. P. DeWeerth, "A Lithographically-Patterned, Elastic Multi-Electrode Array for Surface Stimulation of the Spinal Cord," Biomedical Microdevices, vol. 10, no. 2, pp. 259–269, April 2008.

1. S. P. DeWeerth and L. Guo, "PDMS-Based Neural Interfaces: An Integrated System Solution," Materials Research Society 2010 Spring Meeting, San Francisco, California, April 5-9, 2010.

1. L. Guo and S. P. DeWeerth, "Multilayer Via-Bonding Technology for High-Density, High-Resolution Chip Packaging," 60th Electronic Components and Technology Conference, Las Vegas, Nevada, June 1-4, abstract submitted, 2010.


2. L. Guo, L. J. Kitashima, C. R. Villari, A. M. Klein, and S. P. DeWeerth, "Muscle Surface Recording and Stimulation Using Integrated PDMS-Based Microelectrode Arrays: Recording-Triggered Stimulation for Prosthetic Purposes," talk, IEEE Biomedical Circuits and Systems Conference 2009, Beijing, China, November 26-28, accepted, 2009.


3. L. Guo and S. P. DeWeerth, "Implementation of Integratable PDMS-Based Conformable Microelectrode Arrays Using a Multilayer Wiring Interconnect Technology," 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota, September 2-6, 2009.


4. L. Guo and S. P. DeWeerth, "PDMS-Based Conformable Microelectrode Arrays with Selectable Novel 3-D Microelectrode Geometries for Surface Stimulation and Recording," 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota, September 2-6, 2009.


5. W. Jia, X. Liu, X. Gao, L. Guo, Y. Lei, Y. Ku, and S. Gao, "The Detection of Seizure Vulnerable Period from Epidural EEG Recordings of Epilepsy Rat," The 2nd International IEEE EMBS Conference on Neural Engineering, Washington D.C., March 16-19, 2005.

1. L. Guo, I. P. Clements, R. V. Bellamkonda, and S. P. DeWeerth, "A Regenerative Scaffold Integrated with a PDMS-Based Microelectrode Array for Peripheral Nerve Interfacing," Materials Research Society 2010 Spring Meeting, San Francisco, California, April 5-9, submitted, 2010.


2. L. Guo and S. P. DeWeerth, "High-Density Conformable Microelectrode Arrays for Neural and Muscular Surface Stimulation and Recording," The 39th Annual Meeting of the Society for Neuroscience, Chicago, Illinois, October 17-21, 2009.


3. L. Guo and S. P. DeWeerth, "High Capacity Elastronics," 3rd South-East Workshop on Soft Materials and Interfaces, Atlanta, Georgia, May 15, 2009.


4. L. Guo and S. P. DeWeerth, "Fabrication of Multilayer Wiring Interconnects on PDMS Substrate," talk, Materials Research Society 2009 Spring Meeting, San Francisco, California, April 13-17, 2009.


5. K. K. Williams, L. Guo, S. Hochman, and S. P. DeWeerth, "Elastomer-Based Multi-Electrode Arrays for Activation of Spinal Cord White Matter Tracts: Evaluation of Surface Stimulation Selectivity," The 37th Annual Meeting of the Society for Neuroscience, San Diego, California, November 3-7, 2007.


6. K. K. Williams, L. Guo, S. Hochman, and S. P. DeWeerth, "A Conformable Elastomer-Substrate Microelectrode Array (MEA) for Stimulation of Spinal White Matter Tracts," Cellular and Network Functions of the Spinal Cord 2007 Conference, Madison, Wisconsin, June 12-15, 2007.


7. L. Guo, K. K. Williams, R. J. Giuly, and S. P. DeWeerth, "A PDMS-based Elastic Multi-Electrode Array for Spinal Cord Surface Stimulation and Its Electrode Modification to Enhance Performance," Materials Research Society 2007 Spring Meeting, San Francisco, California, April 9-13, 2007.


8. X. Gao, L. Guo, Y. Lei, and Y. Ku, "A System for Epidural EEG Data Acquisition from a Rat Animal Model," The 2nd World Congress for Chinese Biomedical Engineers, Beijing, China, September 26-29, 2004.